41 Comments

Is there long term side effects to these supplements? Have been interested in trying out the brain type (focus/neuroplasticity) in the past but worried about fucking up my brain/getting depressed or something. Or not being able to focus without them if I stop taking them in the future

Concerns might be unfounded but any thoughts on how to approach these for someone that's curious but also kinda scared

Expand full comment

thoughts on carnivore diet? i am 38 years old, went full carnivore (eat mostly just ribeye and ground beef) back in June 2023. i immediately lost 20 lbs of water and fat, and all my lifts went up, i'm now lifting more at 38 than i was at 23. a few weeks after going carnivore i was able to quit coffee (had been drinking 2-3 cups a day for past 2 decades), quit weed, and get out of a toxic relationship. its amazing the effects that a proper diet can have on your willpower and the cascade of changes it leads to in all areas of your life.

Expand full comment

Great information, thanks Biohacker.

Wha is the 1 supplement from each category, Focus and Neuroplasticity, would you recommend for someone just starting out on this protocol?

Expand full comment

One caveat- Amphetamines caused neuron death in rat studies, no human studies showing this .

Saffron as a Dopamine/NE reuptake inhibitor is how stimulants act, Adderall is a Dopamine/NE reuptake inhibitor. Point being if Adderall/Ritalin can cause neuron death, so could Saffron (dose dependent) as biological mechanism is the same.

Expand full comment

For those already acclimatized to daily stimulant use (e.g. 20mg Adderall IR, 500mg caffeine) do any of your recommendations change? Would you advise a slow taper or immediate stop? Are there special steps you’d take to address the damage?

Expand full comment

Several of references refer to studies only done in rats

Some of these have effects that can be dangerous if mixed with other medications, ie those with MAO inhibitor-type activity

Dosage, side effect profiles, medication interactions not included

Overall outcome measure of neuroplasticity unclear. How is that tested and measured?

Expand full comment

It may be something on your Substack and will check, but given this information, would combination therapy with Transcranial Magnetic Stimulation be too much or a complimentary therapy if someone was to research that? Especially now that don't need visit to a clinic to do TMS with at home units now on market.

Expand full comment

Why not mention BPC-157?

Expand full comment

Funny you mentioned selank and semax. Have run into these from searches along with other peptides. Do you do consults? Might be interested in grabbing 30 mins to do a deeper dive.

Expand full comment

This post is fantastic! Question about the supps. Do you take any of them daily for general brain health? Or are they all for immediate effect?

Expand full comment

Thoughts on zyn/nicotine pouches?

Expand full comment

Great post.

Bull, do you still recommend the Now Chlorella?

Expand full comment

hey biohacker, any experience with psilocybin for neurogenesis, and associated results, improved mood, memory, learning?

not the get high version, the low/micro dosage-long running plan... asking for a friend... ;)

Expand full comment